Agaricus blazei Murill (AbM), also known as Agaricus subrufescens, Himematsutake, or Royal Sun Agaricus, is a functional mushroom known for its rich profile of polysaccharides (beta-glucans and heteroglucans), sterols, and phenolic compounds. These bioactive components have been studied for their potential to support immune function, promote overall well-being, and aid in recovery.
Maintaining overall wellness and supporting the body's natural resilience is important for individuals undergoing chemotherapy. Below is a guide on how Agaricus blazei may be incorporated into wellness routines before, during, and after chemotherapy, along with considerations for safe use.
Before Chemotherapy: Preparing the Body for Resilience
Supporting Immune Function
Agaricus blazei mushrooms contain polysaccharides and beta-glucans, which have been extensively studied for their ability to interact with the body's natural defense mechanisms. Many individuals preparing for chemotherapy focus on nutrient-rich foods and functional ingredients to help maintain overall health.
Promoting Oxidative Balance
Research suggests that phenolic compounds and polysaccharides in Agaricus blazei contribute to oxidative balance, which plays a role in overall well-being. Supporting the body's natural ability to manage oxidative stress is often a priority before starting chemotherapy.
How to Incorporate Agaricus Blazei
The suggested use is to take 3–5g of dried Agaricus blazei daily as a liquid extract, capsule, or powder.
Precautions
- For Surgery & Chemotherapy: Stop using Agaricus blazei 1–2 weeks before any invasive procedures to reduce potential bleeding risks. Agaricus blazei may have mild blood-thinning properties. Caution is advised for individuals taking anticoagulants such as Warfarin, Aspirin, or Heparin, as well as those with bleeding disorders.
During Chemotherapy: Supporting General Wellness
Maintaining Energy and Vitality
Chemotherapy can be physically demanding, and supporting energy levels and well-being is important. Some individuals consider nutrient-dense foods and functional mushrooms part of their overall wellness plan.
Immune and Digestive Support
Agaricus blazei has been studied for its potential impact on gut microbiota and immune signaling pathways. Maintaining gut and immune health is often a consideration for those undergoing chemotherapy, as it can influence overall well-being.
Better Results
Clinical studies report that Agaricus blazei helped alleviate chemotherapy-induced nausea, vomiting, loss of appetite, and fatigue. Another study reports that Agaricus blazei mushroom enhances the effect of doxorubicin (Dox), a chemotherapy drug, by increasing intracellular drug accumulation and apoptosis (cancer cell death).
How to Consume
If the oncologist approves, 3–5g of dried Agaricus blazei daily as a liquid extract, capsule, or powder is suggested. Take it with meals and water.
After Chemotherapy: Recovery and Rejuvenation
Helping Restore Immune System Balance
After completing chemotherapy, individuals often focus on recovery and rebuilding strength. Functional mushrooms like Agaricus blazei contain compounds that may contribute to post-treatment wellness by supporting the body's natural resilience mechanisms.
Oxidative and Inflammatory Balance
Certain polysaccharides and phenolic compounds in Agaricus blazei have been investigated for their role in promoting cellular balance and recovery following periods of physical stress, including medical treatments such as chemotherapy.
The Suggested Use
- Daily intake of extracts or powders (1.2–5 g), as part of an overall wellness plan.
- Take it with meals, smoothies, or water for ongoing support.
Considerations for Safe Use
Agaricus blazei is generally well-tolerated, but individuals should be mindful of potential sensitivities:
- Digestive Sensitivity: Some may experience mild digestive discomfort, such as bloating or changes in bowel habits.
- Blood Sugar Considerations: Some studies suggest that functional mushrooms may influence glucose metabolism. Those monitoring blood sugar levels should consult with a healthcare provider before use.
- Liver Health: While some research suggests potential liver-supportive effects, those with existing liver conditions should monitor their intake and consult with a healthcare professional.
- Platelet Considerations: Rare reports indicate a possible influence on platelet function; those taking blood-thinning medications should seek medical advice before use.
- Allergies: Individuals with mushroom allergies should avoid Agaricus blazei.
Final Thoughts
Maintaining overall well-being, immune health, and vitality is essential for those undergoing chemotherapy. Functional mushrooms like Agaricus blazei may serve as a nutrient-dense addition to a balanced diet, supporting the body's natural immune system functions.
As with any supplement, individual responses may vary, and it is always best to consult a healthcare professional before incorporating Agaricus blazei into your regimen, especially when undergoing chemotherapy or other medical treatments.
References
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- Lee, J. S., & Hong, E. K. (2011). Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NFκB-mediated increase of intracellular doxorubicin accumulation. International Journal of Oncology, 38(2), 401-408. https://doi.org/10.3892/ijo.2010.852
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