Mushroom Ekismate: Your New Secret Weapon to Restore Your Health Naturally

In a world where health has become more precious than ever, individuals turn to nature for solutions to boost their immune systems and overall vitality since our immunity declines as we age. Today, we unveil the Mushroom Ekismate, a supernova in the realm of natural wellness that promises to be an ally for those seeking immune support.

What Is Mushroom Ekismate?

Mushroom Ekismate is not just another health supplement; it's a fusion of ancient wisdom and modern science. Specially designed for adults with weakened immune systems and individuals experiencing chronic fatigue, Mushroom Ekismate serves as Nature's Immune Support Formula. Embedding within it the strength of nature and the assurance of scientific research, it signifies hope and natural health.

A Blend of Quality and Care

Imagine a formula that encapsulates the protective essence of six organic functional mushroom extracts and the potent Sasa bamboo leaf extract – that's Mushroom Ekismate for you. Crafted in the USA with rigorous standards, Mushroom Ekismate relies on both the fruitbodies and mycelium of the fungi to harness their inherent power.

The Power of Six Organic Medicinal Mushrooms in Mushroom Ekismate

At the heart of Mushroom Ekismate are six medicinal mushrooms, each selected for its unique properties that contribute to immune support and overall vitality. These fungi have been revered throughout history for their health benefits and are now harnessed using modern techniques to ensure their potency:

  • Agaricus blazei Murill (Agaricus subrufescens) is known as God's mushroom for its potent immune-boosting properties and ability to support healthy cells by strengthening the activity of immune cells such as NK cells and macrophages. It may help manage the side effects of chemotherapy by counteracting immune suppression. Other research-supported clinical benefits are healthy glycemic and liver support.
  • Reishi (Ganoderma lucidum): Known as the "Mushroom of Immortality," Reishi is used extensively by Traditional Chinese Medicine (TCM) physicians and Japanese Kampo Medicine Practitioners. It supports stress reduction and alleviates fatigue. It may also support immune health before, during, and after chemo and radiation therapy. This adaptogenic medicinal mushroom may also support heart and liver health.
  • Shiitake (Lentinula edodes): Rich in vitamins and minerals and polysaccharides, including lentinan and other beta-glucans that support the immune system and cellular health. Eritadenine and sterol in Shiitake mushrooms support cardiovascular health and boost immunity. Active Hexose Correlated Compound is a well-established dietary supplement derived from Shiitake mushroom mycelium.
  • Maitake (Grifola frondosa): Maitake is renowned for modulating the immune system and supporting healthy blood sugar levels. Clinically studied D-fraction is a water-soluble protein-bound β-1,3/β-1,6-glucan (proteoglucan) found in Maitake mushrooms and is derived from the mushroom's fruiting body.
  • Turkey Tail (Trametes versicolor): This mushroom is packed with antioxidants, including phenols and flavonoids. It also contains immune-boosting polysaccharides such as Polysaccharide K (PSK) and Polysaccharopeptide (PSP). PSK and PSP also support healthy inflammatory responses. PSK and PSP are derived from the mycelium of Trametes versicolor. The Japanese Ministry of Health, Labor, and Welfare (MHLW), equivalent to the U.S. FDA, approved PSK in clinical use in 1977.
  • Cordyceps (Cordyceps militaris and Cordyceps sinensis): Traditionally used to increase energy and endurance, Clinical studies suggest Cordyceps support a healthy immune system, kidney, liver, and respiratory health. Research suggests Cordycepin and Adenosine in Cordyceps mushrooms play essential roles in cellular energy production, circulation, and overall vitality.

Each of these mushrooms brings a spectrum of health benefits that, when combined, create a comprehensive support system for your well-being, making Mushroom Ekismate a standout in the realm of natural health supplements.

What is Sasa Bamboo Leaf Extract?

Green blood is a nickname for Sasa bamboo leaf extract. It earned that nickname because it contains chlorophyll, which, due to its chemical structure, is like hemoglobin in blood, and the body can easily absorb it.

Sasa bamboo leaf extracts also contain polysaccharides, lignin, vitamins B1, B2, C, and K, and many minerals that strengthen blood vessels, including iron, potassium, and zinc. This plant is known for its strong antibacterial and antiseptic properties, leading to its ability to detox the digestive system and relieve bad breath. Additionally, Sasa Bamboo and other bamboo extracts exhibit strong antioxidant activity and actively scavenge the body's free radicals.

Over centuries, the Japanese have discovered many ways to use Sasa bamboo leaf and leaf extracts.  Sasa bamboo leaf extract is used in culinary, Kampo herbal medicine, dietary supplements, cosmetics, tea beverages, soaps, toothpaste, animal feed additives, pet food, and pet supplements. So, it has a very wide range of applications.

Health Benefits of Our Mushroom Complex Formula

Support the immune system: An immune system bolstered with Mushroom Ekismate is one ready to face the daily onslaught of environmental stressors by strengthening Natural Killer (NK) cell functions and macrophage activity.

Increase energy levels: Battling chronic fatigue? Experience a surge in vitality with Mushroom Ekismate's energy-boosting properties by strengthening your immunity with polysaccharides and beta-glucans and replenishing missing nutrients in your diet.

Support Cellular Health: Mushroom Ekismate may support cellular health by polysaccharides in six functional mushrooms and Sasa bamboo leaf extract, including beta-glucans, PSK (Polysaccharide K), lentinan, D-fraction, and NPS (Neutral Polysaccharide).

Support healthy blood glucose levels: Maintaining healthy blood glucose levels is essential, and polysaccharides and beta-glucans in this mushroom complex effectively help in that regard.

Boost antioxidant activity: Polysaccharides from mushroom complex and Sasa bamboo leaf extract are rich in antioxidant properties, which help manage oxidative stress from unhealthy diet, pollution, alcohol, and mental stress.

Convenience in Capsule Form

Are you concerned about difficult-to-swallow health aids? Mushroom Ekismate's benefits are packed into small, easy-to-swallow 300 mg capsules, making your road to robust health smooth and straightforward.

Making the Natural Choice

Mushroom Ekismate is 100% natural, plant-based, and contains the patented SBRx Sasa bamboo leaf extract made in Japan, ensuring it's not only fast-acting but also rooted in a profound legacy of herbal excellence.

With an aging immune system an inevitable phenomenon, starting early with proactive protection is intelligent health management. Mushroom Ekismate presents a unique opportunity to support your body's natural defenses so you can focus on living life to the fullest and leave the worries of weakened immunity behind.

In choosing Mushroom Ekismate, you're not just choosing a supplement; you're making a pact with nature to prioritize your health and well-being. Empower your body with the secret weapon it deserves – Mushroom Ekismate, your partner in the quest for vitality. Let's start strengthening your immune system early before it's too late.

Reference

  1. Hetland G, Tangen JM, Mahmood F, Mirlashari MR, Nissen-Meyer LSH, Nentwich I, Therkelsen SP, Tjønnfjord GE, Johnson E (2020) Antitumor, anti-inflammatory and antiallergic effects of Agaricus blazei mushroom extract and the related medicinal Basidiomycetes mushrooms, Hericium erinaceus and Grifola frondosa: a review of preclinical and clinical studies. Nutrients 12
  2. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP (2004) Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 14:589–594
  3. Mahmood F, Hetland G, Nentwich I, Mirlashari MR, Ghiasvand R, Nissen-Meyer LSH (2019) Agaricus blazei-based mushroom extract supplementation to birch allergic blood donors: a randomized clinical trial. Nutrients 11
  4. Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P (2007) The mushroom Agaricus blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 13:97–102
  5. Fortes RC (2011) The effects of Agaricus sylvaticus fungi dietary supplementation in the metabolism and blood Pressure of patients with colorectal cancer during post surgical phase. Nutr Hosp 26:176–186
  6. Hsu CH, Hwang KC, Chiang YH, Chou P (2008) The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. J Altern Complement Med 14:299–301
  7. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E (2016) Effect of a medicinal Agaricus blazei Murill-based mushroom extract, AndoSan™, on symptoms, fatigue and quality of life in patients with ulcerative colitis in a randomized single-blinded placebo controlled study. PloS One 11:e0150191
  8. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MÁ, Gusi N, Collado-Mateo D (2021) Effects of Ganoderma lucidum and Ceratonia siliqua on blood glucose, lipid profile, and body composition in women with fibromyalgia. Nutr Hosp 38:139–145
  9. Deng Y, Ma J, Tang D, Zhang Q (2021) Dynamic biomarkers indicate the immunological benefits provided by Ganoderma spore powder in post-operative breast and lung cancer patients. Clin Transl Oncol 23:1481–1490
  10. Sargowo D, Ovianti N, Susilowati E, Ubaidillah N, Widya Nugraha A, Vitriyaturrida, Siwi Proboretno K, Failasufi M, Ramadhan F, Wulandari H, Waranugraha Y, Hayuning Putri D (2018) The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients. Indian Heart J 70:608–614
  11. Chiu HF, Fu HY, Lu YY, Han YC, Shen YC, Venkatakrishnan K, Golovinskaia O, Wang CK (2017) Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a random[1]ized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. Pharm Biol 55:1041–104
  12. Klupp NL, Kiat H, Bensoussan A, Steiner GZ, Chang DH (2016) A double-blind, randomized, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome. Sci Rep 6:29540
  13. Donatini B (2014) Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: a preliminary clinical trial. Int J Med Mush[1]rooms 16:497–498
  14. Gao Y, Zhou S, Jiang W, Huang M, Dai X (2003) Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest 32:201–215
  15. Zhang M, Zhang Y, Zhang L, Tian Q (2019) Mushroom polysaccharide lentinan for treating different types of cancers: a review of 12 years clinical studies in China. Prog Mol Biol Transl Sci 163:297–328
  16. Gaullier JM, Sleboda J, Øfjord ES, Ulvestad E, Nurminiemi M, Moe C, Tor A, Gudmundsen O (2011) Supplementation with a soluble β-glucan exported from Shiitake medicinal mush[1]room, Lentinus edodes (Berk.) singer mycelium: a crossover, placebo-controlled study in healthy elderly. Int J Med Mushrooms 13:319–326
  17. Yamaguchi Y, Miyahara E, Hihara J (2011) Efficacy and safety of orally administered Lentinula edodes mycelia extract for patients undergoing cancer chemotherapy: a pilot study. Am J Chin Med 39:451–459
  18. Kamiyama T, Orimo T, Wakayama K, Kakisaka T, Shimada S, Nagatsu A, Asahi Y, Aiyama T, Kamachi H, Taketomi A (2022) Preventing recurrence of hepatocellular carcinoma after curative hepatectomy with active hexose-correlated compound derived from Lentinula edodes mycelia. Integr Cancer Ther 21:15347354211073066
  19. Yanagimoto H, Hirooka S, Yamamoto T, Yamaki S, Sekimoto M (2023) Efficacy of Lentinula edodes mycelia extract on chemotherapy-related tasted disorders in pancreatic cancer patients. Nutr Cancer 75:236–246
  20. Kosaka A, Wani T, Hattori Y, Yamashita A (1982) Effect of lentinan administration of adrenalectomized rats and patients with breast cancer. Gan To Kagaku Ryoho 9:1474–1481
  21. Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves Jr C, Spaiser SJ, Christman MC, Langkamp-Henken B, Percival SS (2015) Consuming Lentinula edodes (Shiitake) mushrooms daily improves human immunity: a randomized dietary intervention in healthy young adults. J Am Coll Nutr 34:478–487
  22. Spim SRV, Pistila AMH, Pickler TB, Silva MT, Grotto D (2021) Effects of Shiitake culinary,[1]medicinal mushroom, Lentinus edodes (Agaricomycetes), bars on lipid and antioxidant profiles in individuals with borderline high cholesterol: a double-blind, randomized clinical trial. Int J Med Mushrooms 23:1–12
  23. Deng G, Lin H, Seidman A, Fornier M, D'Andrea G, Wesa K, Yeung S, Cunningham-Rundles S, Vickers AJ, Cassileth B (2009) A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J Cancer Res Clin Oncol 135:1215–1221
  24. Hu Q, Xie B (2022) Effect of Maitake D-fraction in advanced laryngeal and pharyngeal cancers during concurrent chemoradiotherapy: a randomized clinical trial. Acta Biochim Pol 69:625–632
  25. Wesa KM, Cunningham-Rundles S, Klimek VM, Vertosick E, Coleton MI, Yeung KS, Lin H, Nimer S, Cassileth BR (2015) Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 64:237–247
  26. Zhao F, Guo Z, Ma ZR, Ma LL, Zhao J (2021) Antitumor activities of Grifola frondosa (Maitake) polysaccharide: a meta-analysis based on preclinical evidence and quality assessment. J Ethnopharmacol 280:114395
  27. Kubo K, Nanba H (1996) The effect of maitake mushrooms on liver and serum lipids. Altern Ther Health Med 2:62–66
  28. Li N, Gao X, Pan Y, Liu B, Pang J, Zhao C, Zeng F (2022) Effects of alkaloid-rich extracts obtained from Grifola frondosa on gut microbiota and glucose homeostasis in rats. Food Funct 13:2729–2742
  29. Ma Y, Wu X, Yu J, Zhu J, Pen X, Meng X (2017) Can polysaccharide K improve therapeutic efficacy and safety in gastrointestinal cancer? a systematic review and network meta-analysis. Oncotarget 8:89108–89118
  30. Standish LJ, Wenner CA, Sweet ES, Bridge C, Nelson A, Martzen M, Novack J, Torkelson C (2008) Trametes versicolor mushroom immune therapy in breast cancer. J Soc Integr Oncol 6: 122
  31. Torkelson CJ, Sweet E, Martzen MR, Sasagawa M, Wenner CA, Gay J, Putiri A, Standish LJ (2012) Phase 1 clinical trial of Trametes versicolor in women with breast cancer. Int Sch Res Notices
  32. Piotrowski J, Jędrzejewski T, Kozak W (2015) Immunomodulatory and antitumor properties of polysaccharide peptide (PSP). Postepy Hig Med Dosw (Online) 69:91–97
  33. Kobayashi H, Matsunaga K, Oguchi Y (1995) Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycetes: an overview. Cancer Epidemiol Biomarkers Prev 4:275–281
  34. Maehara Y, Tsujitani S, Saeki H, Oki E, Yoshinaga K, Emi Y, Morita M, Kohnoe S, Kakeji Y, Yano T, Baba H (2012) Biological mechanism and clinical effect of protein-bound polysac[1]charide K (KRESTIN®): review of development and future perspectives. Surg Today 42:8–2
  35. Kai Z, Yongjian L, Sheng G, Yu L (2015) Effect of dongchongxiacao (Cordyceps) therapy on contrast-induced nephropathy in patients with type 2 diabetes and renal insufficiency under[1]going coronary angiography. J Tradit Chin Med 35:422–427
  36. Kang HJ, Baik HW, Kim SJ, Lee SG, Ahn HY, Park JS, Park SJ, Jang EJ, Park SW, Choi JY, Sung JH, Lee SM (2015) Cordyceps militaris enhances cell-mediated immunity in healthy Korean men. J Med Food 18:1164–1172
  37. Ding C, Tian PX, Xue W, Ding X, Yan H, Pan X, Feng X, Xiang H, Hou J, Tian X (2011) Efficacy of cordyceps sinensis in long term treatment of renal transplant patients. Front Biosci (Elite Ed) 3:301–307
  38. Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB (2010) Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. J Altern Complement Med 16:585–590
  39. Li Y, Xue WJ, Tian PX, Ding XM, Yan H, Pan XM, Feng XS (2009) Clinical application of cordyceps sinensis on Immunosuppressive therapy in renal transplantation. Transplant Proc 41:1565–1569
  40. Wang NQ, Jiang LD, Zhang XM, Li ZX (2007) Effect of dongchong xiacao capsule on airway inflammation of asthmatic patients. Chin J Chin Mater Med 32:1566–1568
  41. Liu Y, Guo ZJ, Zhou XW (2022) Chinese cordyceps: bioactive components, antitumor effects and underlying mechanism – a review. Molecules 27
  42. Seki T, Maeda H. (2010) Cancer Preventive Effect of Kumaizasa Bamboo Leaf Extracts Administered Prior to Carcinogenesis or Cancer Inoculation. Anticancer Research 30:111-118
  43. Sato K, Tatsunami R, Nakata A, Komatsu KI, Harakawa S, Nedachi T, Haketa K, Inagawa H, Wakame K.(2021) Effects of Kumaizasa ( Sasa senanensis) Leaf Extract on Innate Immune Regulation in HEK293 Cells and Macrophages. Anticancer Research. 2021 Aug;41(8):4093-4100. doi: 10.21873/anticanres.15212
  44. Fang J, Gao S, Islam R, Teramoto Y, Maeda H. (2020) Extracts of Phellinus linteus, Bamboo (Sasa senanensis) Leaf and Chaga Mushroom (Inonotus obliquus) Exhibit Antitumor Activity through Activating Innate Immunity. Nutrients. 2020 Jul 29;12(8):2279. doi: 10.3390/nu12082279.
  45. Seki T, Kida K, Maeda H. (2010) Immunostimulation-Mediated Anti-tumor Activity of Bamboo (Sasa senanensis) Leaf Extracts Obtained Under 'Vigorous' Condition. Evid Based Complement Alternat Med. 2010 Dec;7(4):447-57. doi: 10.1093/ecam/nen026. Epub 2008 May 7
  46. Sakagami H, Amano S, Yasui T, Satoh K, Shioda S, Kanamoto T, Terakubo S, Nakashima H, Watanabe K, Sugiura T, Kitajima M, Oizumi H, Oizumi T. (2013) Biological interaction between Sasa senanensis Rehder leaf extract and toothpaste ingredients. In Vivo. 2013 Mar-Apr;27(2):275-84.
  47. Matsuta T, Sakagami H, Tanaka S, Machino M, Tomomura M, Tomomura A, Yasui T, Itoh K, Sugiura T、Kitajima M, Oizumi H, Oizumi T. (2012) Pilot clinical study of Sasa senanensis Rehder leaf extract treatment on lichenoid dysplasia. In Vivo 2012 Nov-Dec;26(6):957-62.
  48. Hori M, Yagi M, Nomoto K, Kitano T, Miyazaki R, Yonei Y. (2011) Effect of Kumaizasa (Sasa senanensis Rehder) on the inhibition of advanced glycation end product (AGEs) formation, doi: 14988/pa.2017.0000012527
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